Modern infectious disease epidemiology / Johan Giesecke.

Previous edition: London: Arnold, 2002.

Includes bibliographical references and index.

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Cover; Half Title; Cover Info; Title Page; Copyright Page; Dedication; Contents; Preface to the Third Edition; Introduction; Chapter 1: What Is Special about Infectious Disease Epidemiology?; Some Special Features; Epidemiology and Diagnosis; Envoi; Chapter 2: Definitions; Some General Definitions; Incidence; Prevalence; Denominator; Population at Risk; Case-Fatality Rate or Lethality; Mortality; Definitions Used in Infectious Disease Epidemiology; What Is a Case?; Attack Rate; Primary/Secondary Cases; Index Case; Reproductive Rate; Vector; Transmission Routes; Reservoir versus Source.

Point-Source versus Continuous-Source OutbreakZoonosis; Sexually Transmitted Infections; Control of Communicable Diseases Manual; Incubation Period; Serial Interval; Infectious Period; Generation Time; Latent Period; Epidemic; References; Chapter 3: Descriptive Epidemiology; Time; Place; Person; Table or Diagram?; Statistical Analysis; References; Chapter 4: Risk, Relative Risk and Attack Rate; An Epidemiological Analysis of an Outbreak; Person-to-Person Spread; Summary; References; Chapter 5: The Case Control Study: Odds, Odds Ratio -- The Concept of Confounding; Can We Be Sure of Our ORs?

Some General Points about Case Control StudiesOther Examples of Case Control Studies; Some More Recent Developments; Confounding; Causation; Temporality; Biologic Gradient; Strength of Association; Summary; References; Chapter 6: The Cohort Study: Rates -- The Concept of Bias; Person-Years; Risks and Rates; Bias; Clinical Trials; Placebo-Controlled Trials; Randomized Trials; Double-Blind Trials; Historical Parenthesis: James Lind and Scurvy; Pros and Cons of Case Control and Cohort Studies; Summary; References; Chapter 7: Some Statistical Procedures That Are Often Used in Epidemiology.

Confidence Intervals for ProportionsAn Approximate Estimate; The Confidence Interval of Zero; Significance Testing; The t-Test; The Chi-Squared (x2) Test; Fisher's Exact Test; One-Sided and Two-Sided Testing; General Notes on Significance Tests; Estimating Sample Size; The Smallest Sample Size Possible; Summary; References; Chapter 8: Clinical Epidemiology: Sensitivity, Specificity and Misclassification; Sensitivity and Specificity; Two Examples; Fever and Malaria; Smell and Streptococcal Infection; Positive Predictive Value; A New 2 x 2 Table; Reliability; Validity; Misclassification.

Random MisclassificationNon-Random (or Preferential) Misclassification; Summary; References; Chapter 9: Multivariate Analysis and Interaction; Adjusting for Confounding; Matching; Regression Models; Interaction; Misclassification; Summary; References; Chapter 10: Survival Analysis; Survival Analysis; Terminology; An Illustrative Example; The Difference between Risk and Rate; Summary; Chapter 11: Mathematical Models for Epidemics; Basic Reproductive Rate; What Determines R0?; Estimating R0 in an Outbreak; An Approximate Formula for R0; A Simple Model; Objections to the Model.

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